Lewan, who was a two-time All-American and four year starter at Michigan, was emotional as he hugged NFL Commissioner Roger Goodell and held up his Titans jersey in front of the sold-out crowd at the Radio City Music Hall in New York.
The former Michigan captain is the highest selected U-M player since 2008, when former Michigan offensive tackle Jake Long was selected No. 1 overall by the Miami Dolphins.
At 6-foot-7, 309-pounds, Lewan ran an impressive 4.87 40-yard dash at the NFL Combine, which solidified him as a consensus first round pick by most draft experts.
Michigan coach Brady Hoke came to show support for Lewan, who is also his first 1st round draft pick selected under his watch since accepting the job in January 2011.
The Titans selected Lewan despite some notable off the field issues. He is due in court later this month and is expected to be charged with two counts of assault and battery that resulted from an incident in early December. He is also dealing with allegations that he intimidated the alleged victim in former kicker Brendan Gibbons sexual assault case back to 2009. He has denied those allegations.